Welcome to the Diaz Lab

The Diaz Lab has been busy studying a diverse array of species, organs and tissues on sight and collaboratively. The lab’s theme is exploring normal development in vertebrates but framing differences in timing, size, shape and placement in the context of evolution and pathology.

Currently we have undergraduates working on describing patterns of formation, migration and differentiation of squamate embryo neural crest cells (of over 6 species of squamates; yay Anrichell), the evolution and development of the gecko cranioskeletal complex (yay Vivian, and congratulations on winning a best in category Poster!), and cranioskeletal changes during the water-land transition in the larval frogs with impacts on our understanding on bone homology (yay Ilsa, our latest lab addition!).

Additionally, the lab’s breadth has expanded significantly. We have studied the development of the skull not only in non-avian reptiles and amphibians, but have moved across actinopterygians, birds and mammals (including human embryos!). We also explore muscle development, musculoskletal development and how alterations may impact locomotion in tetrapods. Basically, we like to study atypical organisms as their derived morphologies have been incredibly fruitful to our understanding of constraints in morphological design.

Our project collaborations have also expanded and so have our techniques, bringing us into the genomics of skin pigmentation and pattern formation (using single cell RNA-Seq) to exploring the diversity and development of reptile lungs, with a recent paper led by the Schachner Lab exploring caiman lung morphology (and several other lung projects down the pipeline!). Most exciting is that we have now worked with every living group of bony vertebrate and will continue this trend. We also work with most vertebrate model organisms in the lab haha (so cool). 

We also had recent 2 recent papers published, the first is on the effects of high temperature during incubation and basking of gravid females (squamate embryonic development commences within the maternal oviduct; see the link here for our paper driven by the Sanger Lab ). Our second paper was on the formation of limb musculature (both forelimb and hindlimb) in 3 species of lizards belonging to different families, showing different kinematics and also different morphologies (see link)